RIFAXIMIN-MEDIATED GUT MICROBIOTA REGULATION MODULATES THE FUNCTION OF MICROGLIA AND PROTECTS AGAINST CUMS-INDUCED DEPRESSION-LIKE BEHAVIORS IN ADOLESCENT RAT

Abstract Background Chronic unpredictable mild stress (CUMS) can not only lead to depression-like behavior but also change the composition of the gut microbiome.Regulating the gut microbiome LEAVE IN CONDITIONER UNSCENTED can have an antidepressant effect, but the mechanism by which it improves depressive symptoms is not clear.Short-chain fatty aci

Most COVID-19 cases are mild or asymptomatic and recover well, suggesting that effective immune responses ensue, which successfully eliminate SARS-CoV-2 viruses.However, a small proportion of patients develop severe COVID-19 with pathological immune responses.This indicates that a strong immune system balanced with anti-inflammatory mechanisms is c

The small-molecule ALOE SHAVE CREAM DUSK inhibitor of phosphoglycerate dehydrogenase, NCT-503, reduces incorporation of glucose-derived carbons into serine in vitro.Here we describe an off-target effect of NCT-503 in neuroblastoma cell lines expressing divergent phosphoglycerate dehydrogenase (PHGDH) levels and single-cell clones with CRISPR-Cas9-d

Abstract CELSR3 codes for a planar cell polarity protein.We describe twelve affected individuals from eleven independent families with bi-allelic variants in CELSR3.Affected individuals presented with POE Switches/Injectors an overlapping phenotypic spectrum comprising central nervous system (CNS) anomalies (7/12), combined CNS anomalies and congen